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Tuesday, October 6, 2020 | History

2 edition of Bioassay of chlordane for possible carcinogenicity found in the catalog.

Bioassay of chlordane for possible carcinogenicity

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Published by Dept. of Health, Education, and Welfare, Public Health Service, National Institutes of Health, National Cancer Institute, Division of Cancer Cause and Prevention, Carcinogenesis Program, Carcinogen Bioassay and Program Resources Branch in Bethesda, Md .
Written in English

    Subjects:
  • Chlordan.,
  • Carcinogens.

  • Edition Notes

    Statement[prepared at Tracor Jitco, inc.].
    SeriesDHEW publication ; no. (NIH) 77-808, Carcinogenesis technical report series ; no. 8, National Cancer Institute carcinogenesis technical report series -- no. 8., DHEW publication -- no. (NIH) 77-808.
    ContributionsTracor Jitco, Inc.
    The Physical Object
    Paginationxi, 117 p. :
    Number of Pages117
    ID Numbers
    Open LibraryOL17516886M

    REGULATORY TOXICOLOGY AND PHARMACOLOGY 3, () The Power and Interpretation of the Carcinogenicity Bioassay D. B. CLAYSON,I D. KREWSKI, AND 1. C. MUNRO Health Protection Branch, Health and Welfare Canada, Ottawa, Canada Received Carcinogenicity is a major consideration in the assessment of risks due to environmental Cited by:   Chlordane is a manufactured chemical that was used as a pesticide in the United States from to Technical chlordane is not a single chemical, but is actually a mixture of pure chlordane mixed with many related chemicals. It doesn't occur naturally in the environment. It is a thick liquid whose color ranges from colorless to amber.

    A Toxicological Profile for Chlordane was released on December This edition supersedes any previously released draft or final profile. Toxicological profiles are revised and republished as necessary, but no less than once every three years. For information regarding the update status of previously released profiles contact ATSDR at:File Size: 6MB. Animal Carcinogenicity Studies: 3. Alternatives to the Bioassay Andrew Knight,1 Jarrod Bailey2 and Jonathan Balcombe3 1Animal Consultants International, London, UK; 2School of Population and Health Sciences, Faculty of Medical Sciences, University of Newcastle upon Tyne, Newcastle upon Tyne, UK; 3Physicians Committee for.

    carcinogenicity studies are caused by a non-genotoxic mechanism for which rodents are particularly sensitive, i.e.: continuous release of calcitonin due to persistent . CTAs are faster and more cost efficient than the in vivo rodent carcinogenicity assay, providing a useful approach for screening of chemicals with respect to their carcinogenic : Romualdo Benigni.


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Bioassay of chlordane for possible carcinogenicity Download PDF EPUB FB2

Additional Physical Format: Online version: Bioassay of chlordane for possible carcinogenicity. Bethesda, Md. (OCoLC) Material Type: Government publication. BIOASSAY OF CHLORDANE FOR POSSIBLE CARCINOGENICITY.

Carcinogen Bioassay and Program Resources Branch. Carcinogenesis Program. Division of Cancer Cause and Prevention. National Cancer Institute. National Institutes o f Health. Bethesda, Maryland DHEW Publication No.

(NIH) 8. Get this from a library. Bioassay of chlordane for possible carcinogenicity. [Gulf South Research Institute.; National Institutes of Health (U.S.); Carcinogenesis Program (National Cancer Institute (U.S.)).

Carcinogen Bioassay and Program Resources Branch.;]. The carcinogenesis bioassay of technical grade 1,1,1-Trichloroethane was conducted using Osborne-Mendel rats and B6C3F1 mice.

1,1,1-Trichloroethane was administered orally by gavage in corn oil to 50 animals of each sex and species at two dose levels 5 days per week for 78 weeks. A bioassay of beta-2'-deoxythioguanosine monohydrate (b-TGdR) for possible carcinogenicity was conducted by administering the test chemical by intraperitoneal injection to Sprague-Dawley rats and B6C3F1 mice.

Groups of 35 rats of each sex were administered b-TGdR in a buffered saline and polysorbate 80 vehicle at one of two doses, either A bioassay of technical-grade hydrazobenzene for possible carcinogenicity was conducted using Fischer rats and B6C3F1 mice.

Hydrazobenzene was administered in the feed, at either of two concentrations, to groups of 50 male and 47 to 50 females animals of each species. Chlordane is a chlorinated hydrocarbon used as a non-systemic contact insecticide for lawns and crops.

Actually a complex mixture of isomers, other chlorinated hydrocarbons, and by-products, chlordane is used in termite and ant control, and as a protective treatment for underground cables. Bioassay of trisodium ethylenediaminetetraacetate trihydrate for possible carcinogenicity Published: () Bioassay of parathion for possible carcinogenicity Published: ().

The committee began meeting in January and selected as its first topic of study and use of the maximum tolerated dose (MTD) in animal bioassays, with emphasis on the relationship between the MTD and the carcinogenic potency of a test chemical.

Chlordane was used as a pesticide in the United States from to Inall approved uses of chlordane in the United States were canceled. it is not possible to state whether these effects were solely due to chlordane or to other chemicals as well.

(1,3,7) An animal study reported biochemical and behavioral laterations mimicking. Evidence pertaining to the carcinogenicity of chlordane and heptachlor/heptachlor epoxide is reviewed and evaluated. The report covers studies completed before Case reports and epidemiologic studies of pesticide applicators and pesticide manufacturing workers are reviewed, but because of methodologic limitations, these studies establish neither a positive nor a negative association.

$ Chlordane was used on food and non-food agricultural crops, residential lawns and gardens, and against structural pests, particularly termites (2, 3). $ Chlordane is a chlorinated cyclodiene that is a mixture of closely related chemicals including chlordene, File Size: KB.

The conventional test for carcinogenicity is the long-term rodent carcinogenicity bioassay described in Organisation for Economic Cooperation and Development (OECD) Test Guideline (TG) The objective of this test is “to observe test animals for a major portion of their life span for the development of neoplastic lesions during or after.

In the NCI (b) bioassay of the carcinogenicity of heptachlor, groups of 50 male and 50 female Osborne-Mendel rats and groups of 50 B6C3F1 mice of each sex were maintained on diets containing technical grade heptachlor for 80 weeks plus 21 and 10 weeks of.

To the Editor: In response to the letter by Huff () published in the December issue of Toxicological Sciences, we would like to clarify issues regarding the NTP study of Bisphenol A (BPA).Huff () states that “it appears that BPA exposure via the diet for two years should be considered associated with tumors of the hematopoietic system in rats and mice, and of the testes and of the Cited by: 7.

bioassay, statistical analysis of screening bioassays, quantitative risk assessment, and regulatory considerations. Some references have been included in more than one section, where appropriate. The practical aspects of conducting an adequate and valid carcinogen bioassay are discussed in the references in §2.

Technical chlordane is composed of: 19% cis-chlordane, 24% trans-chlordane, 7% trans-nonachlor, 10% heptachlor, 21% chlordene isomers, and 18% miscellaneous chlorinated products (IARC, ). In more recent years, HCS, a high-purity formulation of chlordane containing over 95% chlordane (~74% cis - and ~24% trans -chlordane) has been Cited by: A full-scale bioassay of chlordane for possible carcinogenicity has been published as a National Cancer Institute (NCI) report and is in the open literature.

Fifty Osborne-Mendel rats and B6C3F1 mice/sex/group were exposed to the compound in laboratory chow for 80 weeks, and then observed for an additional 29 weeks prior to : Emily N. Reinke, Adam T. Deck. Unfortunately, this book can't be printed from the OpenBook. If you need to print pages from this book, we recommend downloading it as a PDF.

Visit to get more information about this book, to buy it in print, or to download it as a free PDF. Animal Carcinogenicity Studies: 3. Alternatives to the Bioassay. carcinogenicity bioassay in the general literature and the potential for the possible incorporation of alternative tests. Technical chlordane, CAS No.is a mixture of chlordane and chlordane related compounds having a lower percentage of the cis and trans isomers and a larger percentage of other compounds relative to mixtures with the above CAS number.

Dearth and Hites () identified different compounds in a preparation of technical Size: KB.Full text of "Bioassays of aldrin and dieldrin for possible carcinogenicity" See other formats.NCI () National Cancer Institute.

Bioassay of chlordane for possible carcinogenicity. NCI Carcinogenesis Tech Rept Ser. no. 8. NCI, Bethesda, Maryland. p. [Also published as U.S.

Dept of Health, Education and Welfare (Washington, DC) Publication no. (NIH) B] Google Scholar.